Concerned about PE? The importance of early diagnosis

cancer treatment and diagnose, palliative care
A Momentous Shift in Cancer Care
April 25, 2017
Health care vs car care
What men’s health, their cars, and gadgets do not have in common
May 23, 2017
preeclampsia, maternal care, neonatal diagnostics, perinatal

Preeclampsia – the most common complication during pregnancy.

It affects between 2% – 10% of pregnancies worldwide with the impact of the disease being more prevalent in developing countries.

A  significant number of deaths occur annually according to a study published online:

  • in Africa more than 270,000 women

  • worldwide approximately 76,000 women

  • 500,000 babies

The lack of knowledge about preeclampsia is cited as one of the major reasons why preventive actions are not taken.

In order to reduce the rates of preeclampsia the country’s healthcare system should focus on:

  • supplying better access to appropriate obstetric care, particularly during labour and delivery

  •  improve screening and treatment of identified cases

Herewith a recent article published in The Medical Chronical on the importance of early diagnosis of PE.

Early diagnosis of preeclampsia (PE) can improve maternal and perinatal outcome

PE is a pregnancy complication that causes high blood pressure, kidney damage, and other problems. It refers to the onset of hypertension with proteinuria and/or end-organ dysfunction after 20 weeks of gestation in a previously normotensive woman.

The clinical manifestations of PE can appear anytime from the late second trimester to the first few weeks postpartum. The condition stems in early pregnancy and is characterised by abnormal remodeling of the maternal spiral arteries at the placental site.

Early diagnosis may improve maternal and perinatal outcome by ensuring appropriate management (eg, antenatal corticosteroids for fetal lung maturation, treatment of severe hypertension, and early delivery).

The best ways of predicting PE involve multiparametric approaches, using a variety of parameters in combination (such as established in first-trimester aneuploidy screening). A combination of maternal risk factors, the uterine artery pulsatility index (PI), mean arterial pressure (MAP), and maternal serum pregnancy-associated plasma protein-A (PAPP-A), placental growth factor (PlGF), PP13, and fetal haemoglobin levels at 11-13 weeks’ gestation can be used to identify a high proportion of pregnancies at high risk for early onset PE.

  • Anti-angiogenic markers

Research shows that angiogenic markers are useful in diagnosis aa well as prediction and management of PE and placenta-related disorders. PlGF circulates free or in complexes with fms-like tyrosine kinase-1. PlGF in screening for PE is used for early onset disease.

Defective early placentation with impaired trophoblast invasion and restricted remodeling of the spiral arteries are central to early-onset PE, resulting in reduced uteroplacental perfusion. The combination of second- and third-trimester sFlt-1/PlGF ratios gives a detection rate of 87% at a fixed false-positive rate of 10% for early prediction of PE in a low-risk population.

  • PAPP-A

PAPP-A is a large highly glycosylated protein that is produced by developing trophoblast cells. It has been shown to be a syncytiotrophoblast-derived, insulin-like growth factor binding protein protease. The insulin-like growth factor system is believed to play an important role in placental growth and development. So, low serum PAPP-A levels are associated with a higher incidence of PE. Increased maternal serum PAPP-A levels have been observed in established PE.

Predictive models for estimating individualised risk estimates for late-onset PE are based on a combination of first-trimester levels of PAPP-A and the second-trimester sFlt-1/PlGF ratio (detection rate of 87% at a fixed false-positive ratio of 5%).

In pregnancies with the development of PE, the maternal serum concentrations of PlGF and PAPP-A are reduced. These proteins are produced by the trophoblast, and their reduced maternal serum concentrations presumably reflect impaired placentation.
References available on request.

Acknowledgment for this article goes to Medical Chronicle.